T Diabetes Cells
Type 1 diabetes (t1d) is a chronic t-cell mediated disease that leads to the destruction of the insulin-secreting islet β-cells (figure 1) resulting in absolute insulin deficiency and hyperglycaemia. Type 1 diabetes (t1d) is a chronic autoimmune disease that causes severe loss of pancreatic β cells. autoreactive t diabetes cells t cells are key mediators of β cell destruction. Type 1 diabetes is polygenic disease with a strong genetic component. the major susceptibility locus for t1d maps to the hla region on chromosome 6p21 and this accounts for 30-50% of the genetic risk; specifically, these are the loci hla-drb1 and hla-dqb1. the highest risk dr/dq haplotypes for t1d are dr3-dqa1*0501-dqb1*0201 (dr3) and dr4-dqa1*0301-dqb1*0302 (dr4). in addition, more than 40 non-hla, loci have been confirmed which impart a smaller effect on disease risk − these include the insulin gene, ctla-4, ptnp22, and il-2ra. © the copyright for this work resides with the author. Why diabetes damages your bod...